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03-34-0051 Calpeptin - CAS 117591-20-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
117591-20-5C₂₀H₃₀N₂O₄

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      Description
      OverviewA cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
      Catalogue Number03-34-0051
      Brand Family Calbiochem®
      SynonymsBenzyloxycarbonylleucyl-norleucinal
      References
      ReferencesLee, M.S., et al. 2000. Nature 405, 360.
      Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
      Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
      Shiba, E., et al. 1996. Anticancer Res. 16, 773.
      Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
      Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
      Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
      Product Information
      CAS number117591-20-5
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₀H₃₀N₂O₄
      Chemical formulaC₂₀H₃₀N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCalpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)
      Biological Information
      Primary TargetCalpain-1
      Primary Target IC<sub>50</sub>ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
      Purity≥94% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Nle-CHO
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      03-34-0051-5MG 04055977206852