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220201 CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem

CAS 75621-03-3 is a zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

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220201
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
75621-03-3C₃₂H₅₈N₂O₇S

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      220201-25GM
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          Description
          OverviewZwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than structurally-related carboxylic acid anions and is much more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100 Detergent. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding of opiates. Also, capable of disaggregating cytochrome P450 to its monomeric form without denaturation. Has a small micellar molecular weight and a high critical micellar concentration and can be removed from either gels or protein solutions by dialysis across a membrane. Aggregation number: 4-14.
          Conductivity (1.0 M, 24°C): <100 µmhos.
          Catalogue Number220201
          Brand Family Calbiochem®
          Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
          References
          ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
          Ofri, D., et al. 1992. J. Neurochem. 58, 628.
          Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
          Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
          Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
          Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
          Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.
          Product Information
          CAS number75621-03-3
          Aggregation Number4 - 14
          CMC6 - 10 mM
          FormWhite crystalline powder
          Hill FormulaC₃₂H₅₈N₂O₇S
          Chemical formulaC₃₂H₅₈N₂O₇S
          Hygroscopic Hygroscopic
          Micellar weight6150
          Quality LevelMQ300
          Applications
          Biological Information
          Purity≥98% by NMR
          Physicochemical Information
          ContaminantsDNase, RNase, and Protease: none detected
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22-36/38

          Harmful if swallowed.
          Irritating to eyes and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +15°C to +30°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          220201-1GM 04055977200973
          220201-25GM 04055977201000

          Documentation

          CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          220201

          References

          Reference overview
          Chen, Y., et al. 1992. Biochemistry 31, 2415.
          Ofri, D., et al. 1992. J. Neurochem. 58, 628.
          Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
          Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
          Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
          Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
          Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.

          Brochure

          Title
          Biological Detergents Brochure
          Bulk Product Guide
          CALBIOSORBﾙ Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-November-2010 RFH
          Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
          DescriptionNon-denaturing zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than the structurally related carboxylic acid anions, and is more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding to opiates. Also capable of disaggregating P 450 to its monomeric form without denaturation. Has a small micellar molecular weight (6150 Daltons) and a high critical micellar concentration (6-10 mM). Can be removed from either gels or protein solutions by dialysis. Aggregation number: 4-14.
          FormWhite crystalline powder
          CAS number75621-03-3
          Chemical formulaC₃₂H₅₈N₂O₇S
          Purity≥98% by NMR
          ContaminantsDNase, RNase, and Protease: none detected
          SolubilityH₂O (1.0 M)
          Storage +15°C to +30°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Toxicity Harmful
          Merck USA index14, 2044
          ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
          Ofri, D., et al. 1992. J. Neurochem. 58, 628.
          Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
          Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
          Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
          Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
          Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.