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178276 Apicidin, Fusarium sp. - Calbiochem

A potent, cell-permeable inhibitor of histone deacetylase (IC₅₀= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties.

Apicidin, Fusarium sp. - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI

Primary Target: Histone deacetylase
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178276
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₄H₄₉N₅O₆

Pricing & Availability

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178276-5MG
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      Description
      OverviewA potent, cell-permeable inhibitor of histone deacetylase (IC50= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC50= 50-100 nM) and induces the transcriptional activation of p21 (WAF1). Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2.
      Catalogue Number178276
      Brand Family Calbiochem®
      Synonymscyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
      References
      ReferencesColletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
      Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
      Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
      Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
      Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₄H₄₉N₅O₆
      Chemical formulaC₃₄H₄₉N₅O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHistone deacetylase
      Primary Target IC<sub>50</sub>700 pM for parasitic histone deactetylase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      178276-5MG 04055977222418

      Documentation

      Apicidin, Fusarium sp. - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Apicidin, Fusarium sp. - Calbiochem Certificates of Analysis

      TitleLot Number
      178276

      References

      Reference overview
      Colletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
      Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
      Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
      Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
      Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-February-2019 JSW
      Synonymscyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
      DescriptionA potent, cell-permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deactetylase) that also exhibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC50 = 50-100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2 in a reversible manner.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₄H₄₉N₅O₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Highly Toxic
      ReferencesColletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
      Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
      Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
      Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
      Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.