Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
Our tools for studying ubiquitination will help you understand the biological role and importance of the ubiquitin-proteasome pathway that has been implicated in several forms of malignancy and in the pathogenesis of several genetic diseases.
Speed your time to discovery by leveraging our target profiling services, multiplex and traditional immunoassays, and clinical lab contract services that help you prioritize potential drug candidates, screen many biomarkers simultaneously, and conduct research and clinical studies. Our offerings encompass: drug discovery, target profiling and multiplexing.
Proteins are generally believed to move between the compartments of the secretory pathway by budding and fusion of transport vesicles between successive compartments.
Proteins and enzymes are vital parts of organisms participating in almost every process and performing functions that include transport of molecules, DNA replication, catalysis, and responding to stimuli. We offer thousands of highly qualified proteins within an extensive group of subcategories.
Antibodies and assays are offered with breadth and depth in major research areas: Neuroscience, Epigenetics, Cell Signaling, Cancer and Cell Structure, backed by excellent service and support.
Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. Understanding histone modifications is key to uncovering epigenetic mechanisms of gene regulation. Merck grasps the complexity of this research and provides a growing line of kits, antibodies, and assays for studying histones and their modifications. Merck offers over 600 validated antibodies, recombinant proteins, and kits to analyze histone and histone-variant phosphorylation, methylation, acetylation, ubiquitination, and citrullination-the most widely studied histone modifications in epigenetics today.
We provide bulk reagents Proteins and Enzymes along with our bulk reagents, across a range of subcategories from Cytokines and Growth Factors to Substrate Proteins and Peptides.
Chromatin is a complex molecule that can be found in either an open decondensed or active state (euchromatin) or in a tightly compacted inactive state (heterochromatin). Merck also offers a wide selection of ChIP-qualified antibodies against modified and unmodified histones, transcription factors, chromatin modifying proteins and other key chromatin associated proteins.