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Histone Modifications | Life Science Research | Merck
Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. The most commonly studied histone modifications are acetylation, phosphorylation, methylation, and ubiquitination. -
Antibodies to Acetylated and Deacetylated Proteins | Life Science Research | Merck
We offer a selection of assay kits and antibodies to measure acetylation and deacetylation activity, helping to elucidate the relationship between chromatin modification pathways and gene regulation. -
Histone Peptide Arrays | Life Science Research | Merck
Histone peptide arrays are essential screening tools to evaluate the specificity and cross-reactivity of antibodies against histones H2A, H2B, H3, H4, and their post-translational modifications.The arrays are designed on PVDF membranes for a simple Western blot-like assay. -
Cellular Senescence | Life Science Research | Merck
Cellular senescence is the point at which our cells stop dividing and growing due to damage or lack of necessary components. As cells age, they lose their ability to actively divide and start to undergo senescence. -
TFA | Life Science Research | Merck
Transcription or posttranscriptional regulation (TFA) gene change affects the level or localization of protein expression. Characterization of the regulatory machinery is essential for understanding and potentially modulating biological responses encoded in genomic (and epigenomic) information. -
Genomic instability | Life Science Research | Merck
Learn about the environmental factors that can hinder DNA repair. There are many evidence linking genomic and epigenomic changes to disorders involving accelerated aging. Evidence points to general physiological stress and disrupted circadian. It is also possible that decreased DNA repair is also a symptom, not a cause, of aging. To investigate this possibility, researchers will need to examine changes in transcriptional regulators of repair genes, such as ncRNAs, hormones, and other chromatin modulators. -
DNA Damage & TUNEL Assays | Life Science Research | Merck
DNA damage and TUNEL assays are used to examine DNA fragmentation in apoptosis to get some data about DNA damage as it is related to the apoptotic process. -
ChIP Kits | Life Science Research | Merck
ChIP kits selection guide provides you with more information and details about each type of ChiPs : Description, Number of assays, Assay time, Availability with protein A or G, Agarose or Magnetic, etc.. -
RIP Kits | Life Science Research | Merck
RIP kits Selection Guide gives more information and details about each type of RIP Kits: Description, Number of assays, Assay time, Availability with protein A or G, Agarose or Magnetic, etc..