Glycosylated Amino Acids

All N- and O-linked oligosaccharide amino acid derivatives offered by the Novabiochem® brand are compatible with standard protocols in Fmoc solid phase peptide synthesis. Due to the high cost of these reagents, their introduction is best carried out manually using small reagent excesses and the coupling checked using the TNBS or Kaiser test. Any standard coupling method can be used for this purpose.

Following chain assembly, removal of the acetyl protecting group can be carried out by treatment of the peptidyl resin with methanolic ammonia or sodium methoxide/DMF/methanol, or by treatment of the cleaved peptide with catalytic sodium methoxide in methanol.

All N- and O-linked oligosaccharide amino acid derivatives offered by the Novabiochem® brand are compatible with standard protocols in Fmoc solid phase peptide synthesis. Due to the high cost of these reagents, their introduction is best carried out manually using small reagent excesses and the coupling checked using the TNBS or Kaiser test. Any standard coupling method can be used for this purpose. Following chain assembly, removal of the acetyl protecting group can be carried out by treatment of the peptidyl resin with methanolic ammonia or sodium methoxide/DMF/methanol, or by treatment of the cleaved peptide with catalytic sodium methoxide in methanol.