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506181 p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem

p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: TAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic

Primary Target: Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth
506181
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概述

Replacement Information

重要规格表

Empirical Formula
C₁₅₀H₂₂₇N₅₇O₃₂S₂

Products

产品目录编号包装 数量 / 包装
506181-500UGCN 塑胶安瓿;塑胶针药瓶 500 μg
Description
OverviewThe p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.
Catalogue Number506181
Brand Family Calbiochem®
SynonymsTAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
References
ReferencesYamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
Schwarze, S.R., et al. 1999. Science 285, 1569.
Product Information
ATP CompetitiveN
FormLyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
Chemical formulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Applicationp75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.
Biological Information
Primary TargetBlocker of MAG- and Nogo-induced inhibition of neurite outgrowth
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
disulfide bond (12-26)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
506181-500UGCN 04055977272413

Documentation

p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem 分析证书

标题批号
506181

参考

参考信息概述
Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
Schwarze, S.R., et al. 1999. Science 285, 1569.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-August-2008 RFH
SynonymsTAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
DescriptionThe p75NTR inhibitor Pep5 (Cat. No. 506180) fused to the N-terminal, 11-amino acid protein transduction domain sequence from the HIV TAT protein for membrane permeability. Show to inhibit the association of p75NTR with Rho-GDI in vitro. Reported to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion (DRG) and postnatal cerebellar neurons at a concentration of 100 nM. Reported to be a potential therapeutic agent for the inhibition of regeneration in the central nervous system.
FormLyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
Peptide SequenceH₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
disulfide bond (12-26)
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesYamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
Schwarze, S.R., et al. 1999. Science 285, 1569.