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14-486M p70 S6 Kinase Protein, active, 250 µg

Active, N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase, for use in Kinase Assays.

p70 S6 Kinase Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-486M
250 µg  Also available in 10 μg size (cat#14-486) and in bulk (cat# 14-486-K).
Purchase on Sigma-Aldrich

概述

Replacement Information
Description
Catalogue Number14-486M
Brand Family Upstate
Trade Name
  • Upstate
Descriptionp70 S6 Kinase Protein, active, 250 µg
OverviewN-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, N-terminal His6-tagged, recombinant amino acids 1-421 of human p70 S6 kinase, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceExpressed in Sf21 cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Gene Symbol
  • RPS6KB1
  • p70-alpha
  • p70S6k
  • p70-S6K
  • p70
  • S6K
  • S6Kalpha)
  • P70S6K
  • STK14A
  • S6K1
  • p70(S6K)-alpha
  • PS6K
Protein Targetp70S6K
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyAGC
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.
SIZE: 525 amino acids; 59140 Da
SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
Molecular Weight48.7kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of S6 Kinase/Rsk-2 Substrate Peptide 2
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-486) and in bulk (cat# 14-486-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
14-486M 04053252329647

相关产品和应用

Alternative Packsize

产品目录编号 描述
14-486 p70 S6 Kinase Protein, active, 10 µg

产品族

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种类

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases