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482740 nNOS - PSD-95 Interaction Inhibitor, ZL006 - Calbiochem

The nNOS - PSD-95 Interaction Inhibitor, ZL006 controls the biological activity of nNOS. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 5-(3,5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid

482740
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概述

Replacement Information

重要规格表

Empirical Formula
C₁₄H₁₁Cl₂NO₄

Products

产品目录编号包装 数量 / 包装
482740-10MGCN 玻璃瓶 10 mg
Description
OverviewA cell-permeable and blood-brain barrier-permeant aminosalicylic acid compound that selectively disrupts nNOS and PSD-95 interaction upon NMDAR activation both in primary murine cortical neurons (0.8- and 2.8-fold increase from basal level with or without 30 min 10 uM ZL006 pretreatment) in vitro and in mice (0.4- and 1.9-fold increase from basal level with or without inhibitor pretreatment 15 min before ischemia; 1.5 mg/kg i.v.) in vivo without affecting nNOS activity or non-nNOS-mediated NMDAR EPSCs (excitatory postsynaptic currents). Effectively reduce ischemia-caused brain tissue damage in both mice and rats when applied 1 h after blood reperfusion following ishemia (60% and 50% reduction of infarction, respectively; 1.5 mg/kg i.v.).
Catalogue Number482740
Brand Family Calbiochem®
Synonyms5-(3,5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid
References
ReferencesZhou, L., et al. 2010. Nature Med. 16, 1439.
Product Information
FormOff-white solid
Hill FormulaC₁₄H₁₁Cl₂NO₄
Chemical formulaC₁₄H₁₁Cl₂NO₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
482740-10MGCN 04055977200638

Documentation

nNOS - PSD-95 Interaction Inhibitor, ZL006 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

nNOS - PSD-95 Interaction Inhibitor, ZL006 - Calbiochem 分析证书

标题批号
482740

参考

参考信息概述
Zhou, L., et al. 2010. Nature Med. 16, 1439.

小册子

标题
Pathways and Biomarkers of Oxidative Stress
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-September-2012 JSW
Synonyms5-(3,5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid
DescriptionA cell-permeable and blood-brain barrier-permeant aminosalicylic acid compound that selectively disrupts nNOS and PSD-95 interaction upon NMDAR activation both in primary murine cortical neuron cultures (0.8- and 2.8-fold increase from basal level with or without 30 min 10 uM ZL006 pretreatment before 30 min Glu-Gly stimulation) in vitro and in mice subjected to middle brain artery occlusion (0.4- and 1.9-fold increase from basal level with or without inhibitor pretreatment 15 min before MACO; 1.5 mg/kg i.v.) in vivo without affecting nNOS activity or non-nNOS-mediated NMDAR EPSCs (excitatory postsynaptic currents) in rat hippocampus. Its therapeutic efficacy in limiting ischemia-caused brain tissue damage has been demonstrated in both mice and rats when applied 1 h after blood reperfusion following MACO (60% and 50% reduction of infarction, respectively; 1.5 mg/kg i.v.).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₁₁Cl₂NO₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesZhou, L., et al. 2010. Nature Med. 16, 1439.