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691400 Zebularine - CAS 3690-10-6 - Calbiochem

A cell-permeable chemically stable cytidine analog that displays antitumor properties.

Zebularine - CAS 3690-10-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside

Primary Target: Cytidine deaminase
691400
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
3690-10-6C₉H₁₂N₂O₅

Products

产品目录编号包装 数量 / 包装
691400-10MGCN 塑胶安瓿;塑胶针药瓶 10 mg
691400-25MGCN 塑胶安瓿;塑胶针药瓶 25 mg
Description
OverviewA cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
Catalogue Number691400
Brand Family Calbiochem®
Synonyms1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
References
ReferencesCheng, J.C., et al. 2004. Cancer Cell 6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
Frick, L., et al. 1989. Biochemistry 28, 9423.
Product Information
CAS number3690-10-6
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₉H₁₂N₂O₅
Chemical formulaC₉H₁₂N₂O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCytidine deaminase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


From Catalog:
Desc. Field- added "cell-permeable
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
691400-10MGCN 04055977225105
691400-25MGCN 04055977225112

Documentation

Zebularine - CAS 3690-10-6 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Zebularine - CAS 3690-10-6 - Calbiochem 分析证书

标题批号
691400

参考

参考信息概述
Cheng, J.C., et al. 2004. Cancer Cell 6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
Frick, L., et al. 1989. Biochemistry 28, 9423.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-September-2008 RFH
Synonyms1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
DescriptionA chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number3690-10-6
Chemical formulaC₉H₁₂N₂O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or Methanol (5 mg/ml). Slight warming may be required to achieve complete solubilization.
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


From Catalog:
Desc. Field- added "cell-permeable
Toxicity Standard Handling
ReferencesCheng, J.C., et al. 2004. Cancer Cell 6, 151.
Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
Frick, L., et al. 1989. Biochemistry 28, 9423.