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23-056M XIAP, active

XIAP, active MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Enzyme Assays Entrez Gene Number: NM_001167
23-056M
250 µg  
Purchase on Sigma-Aldrich

概述

Replacement Information
Description
Catalogue Number23-056M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionXIAP, active
Alternate Names
  • Baculoviral IAP repeat-containing protein 4 (BIRC4)
  • IAP-like protein
  • Inhibitor of apoptosis protein 3 (API3)
Background InformationX-linked inhibitor of apoptosis (XIAP) is one of a group of intracellular proteins which have been shown to act as endogenous inhibitors of caspases, the enzymatic effectors of apoptosis. XIAP possesses a C-terminal RING domain that functions as an E3 ubiquitin ligase and is able to ubiquitinate a variety of substrates thereby affecting a broad range of cellular activities beyond apoptotic suppression. There is evidence that XIAP plays a significant role in cell division, morphogenesis, heavy metal homeostasis, NF-kB activation and MAP kinase signalling. XIAP expression has been shown to be elevated in several malignancies and so is considered a promising target in anticancer therapies.
References
Product Information
Quality LevelMQ100
Applications
Key Applications
  • Enzyme Assays
Biological Information
Cascade ComponentE3
Entrez Gene Number
Purification MethodPurified using glutathione sepharose, followed by gel filtration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size250 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
23-056M 04053252919053

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产品目录编号 描述
23-056 XIAP, active

产品族

Ubiquitin Proteasome System: Enzymes and Substrates

Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
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种类

Life Science Research > Proteins and Enzymes > Other Proteins