Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

681671 Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem

Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I

681671
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

CAS #Empirical Formula
686770-61-6C₂₂H₁₈N₄O₂S₃

Products

产品目录编号包装 数量 / 包装
681671-10MGCN 塑胶安瓿;塑胶针药瓶 10 mg
Description
OverviewA cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072).
Catalogue Number681671
Brand Family Calbiochem®
SynonymsInhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I
References
ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.
Product Information
CAS number686770-61-6
FormOff-white solid
Hill FormulaC₂₂H₁₈N₄O₂S₃
Chemical formulaC₂₂H₁₈N₄O₂S₃
Quality LevelMQ100
Applications
ApplicationWnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-24/25-36-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
681671-10MGCN 04055977225198

Documentation

Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem 分析证书

标题批号
681671

参考

参考信息概述
Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-February-2014 JSW
SynonymsInhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I
DescriptionA cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number686770-61-6
Chemical formulaC₂₂H₁₈N₄O₂S₃
Purity≥97% by HPLC
SolubilityDMSO (2.5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.