681665 Sigma-AldrichWnt Agonist - CAS 853220-52-7 - Calbiochem
Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).
More>> Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM). Less<<Wnt Agonist - CAS 853220-52-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
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概述
重要规格表
CAS # | Empirical Formula |
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853220-52-7 | C₁₉H₁₈N₄O₃ |
Products
产品目录编号 | 包装 | 数量 / 包装 | |
---|---|---|---|
681665-5MGCN | 塑胶安瓿;塑胶针药瓶 | 5 mg |
Description | |
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Overview | A cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC50 > 60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664). |
Catalogue Number | 681665 |
Brand Family | Calbiochem® |
Synonyms | 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I |
References | |
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References | Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987. |
Product Information | |
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CAS number | 853220-52-7 |
ATP Competitive | N |
Form | Yellowish sticky solid |
Hill Formula | C₁₉H₁₈N₄O₃ |
Chemical formula | C₁₉H₁₈N₄O₃ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications | |
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Application | Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM). |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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产品目录编号 | GTIN |
681665-5MGCN | 04055977260236 |