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681665 Wnt Agonist - CAS 853220-52-7 - Calbiochem

681665
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概述

重要规格表

CAS #Empirical Formula
853220-52-7C₁₉H₁₈N₄O₃

Products

产品目录编号包装 数量 / 包装
681665-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC50 > 60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664).
Catalogue Number681665
Brand Family Calbiochem®
Synonyms2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
References
ReferencesLiu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
Product Information
CAS number853220-52-7
ATP CompetitiveN
FormYellowish sticky solid
Hill FormulaC₁₉H₁₈N₄O₃
Chemical formulaC₁₉H₁₈N₄O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationWnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).
Biological Information
Primary TargetSelective activator of Wnt signaling
Primary Target IC<sub>50</sub>EC50 = 700 nM inducing β-catenin and TCF (T-cell fate)-dependent transcriptional activity in HEK-293T cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
产品目录编号 GTIN
681665-5MGCN 04055977260236