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681525 Sigma-AldrichWiskostatin - CAS 253449-04-6 - Calbiochem

A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly.

Wiskostatin - CAS 253449-04-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: N-WASP (neural Wiskott Aldrich syndrome protein)

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
253449-04-6	C₁₇H₁₈Br₂N₂O

Products

产品目录编号	包装	数量 / 包装
681525-1MGCN	塑胶安瓿;塑胶针药瓶	1 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹
681525-5MGCN	塑胶安瓿;塑胶针药瓶	5 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.
Catalogue Number	681525
Brand Family	Calbiochem®

References
References	Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747. Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.

Product Information
CAS number	253449-04-6
ATP Competitive	N
Form	White solid
Hill Formula	C₁₇H₁₈Br₂N₂O
Chemical formula	C₁₇H₁₈Br₂N₂O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	N-WASP (neural Wiskott Aldrich syndrome protein)
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
681525-1MGCN	04055977260090
681525-5MGCN	04055977260106

Documentation

Wiskostatin - CAS 253449-04-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Wiskostatin - CAS 253449-04-6 - Calbiochem 分析证书

标题	批号
681525	输入批号

参考

参考信息概述
Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747. Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-April-2008 RFH
Description	A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of neural Wiskott Aldrich Syndrome protein (N-WASP). Reported to bind to N-WASP, stabilize the auto-inhibited conformation, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	253449-04-6
Chemical formula	C₁₇H₁₈Br₂N₂O
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747. Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Extracellular Matrix, Adhesion and Cytoskeletal Research Tools

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