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679101 Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem

CAS 32222-06-3 prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 1,25-(OH)₂-D₃, Calcitriol

679101
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
32222-06-3C₂₇H₄₄O₃

Products

产品目录编号包装 数量 / 包装
679101-50UGCN 玻璃瓶 50 μg
Description
OverviewHas immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes. Regulates c-myc transcription. Induces reversible hydrolysis of sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Also available as a 1 mM solution in DMSO (Cat. No. 509721).
Catalogue Number679101
Brand Family Calbiochem®
Synonyms1,25-(OH)₂-D₃, Calcitriol
References
ReferencesSemizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
Mathieu, C., et al. 1994. Diabetologica 37, 552.
Thomasset, M. 1994. Pathol. Biol. 42, 163.
Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
Product Information
CAS number32222-06-3
FormSolid
Hill FormulaC₂₇H₄₄O₃
Chemical formulaC₂₇H₄₄O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSFZ4645000
Safety Information
R PhraseR: 26/27/28-63

Very toxic by inhalation, in contact with skin and if swallowed.
Possible risk of harm to the unborn child.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
679101-50UGCN 07790788052348

Documentation

Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem 分析证书

标题批号
679101

参考

参考信息概述
Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
Mathieu, C., et al. 1994. Diabetologica 37, 552.
Thomasset, M. 1994. Pathol. Biol. 42, 163.
Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-August-2021 JSW
Synonyms1,25-(OH)₂-D₃, Calcitriol
DescriptionActive hormonal form of vitamin D, formed by the renal 1-hydroxylation of 25-(OH)D3. Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, which are an animal model of human autoimmune diabetes. Induces reversible hydrolysis of the sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Involved in cellular differentiation, carcinogenesis, and insulin secretion.
FormSolid
Intert gas (Yes/No) Packaged under inert gas
CAS number32222-06-3
RTECSFZ4645000
Chemical formulaC₂₇H₄₄O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol
Storage Protect from light
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Merck USA index14, 1644
ReferencesSemizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
Mathieu, C., et al. 1994. Diabetologica 37, 552.
Thomasset, M. 1994. Pathol. Biol. 42, 163.
Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.