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616400 Tranilast - CAS 53902-12-8 - Calbiochem

616400
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
53902-12-8C₁₈H₁₇NO₅

Products

产品目录编号包装 数量 / 包装
616400-10MGCN 塑胶安瓿;塑胶针药瓶 10 mg
Description
OverviewAn anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
Catalogue Number616400
Brand Family Calbiochem®
SynonymsN-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
References
ReferencesKoyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
Product Information
CAS number53902-12-8
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₈H₁₇NO₅
Chemical formulaC₁₈H₁₇NO₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetVEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDG8731000
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
616400-10MGCN 04055977185683

Documentation

Tranilast - CAS 53902-12-8 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Tranilast - CAS 53902-12-8 - Calbiochem 分析证书

标题批号
616400

参考

参考信息概述
Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2008 RFH
SynonymsN-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
DescriptionAn anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number53902-12-8
RTECSDG8731000
Chemical formulaC₁₈H₁₇NO₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Toxicity Harmful
Merck USA index14, 9570
ReferencesKoyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.