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648492 TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem

The TRPM4 inhibitor, 9-Phenanthrol, also referenced under CAS 484-17-3, controls the biological activity of TRPM4. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Phenanthren-9-ol, 9-Hydroxyphenanthrene

648492
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
484-17-3C₁₄H₁₀O

Products

产品目录编号包装 数量 / 包装
648492-50MGCN 玻璃瓶 50 mg
Description
OverviewA cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents.
Catalogue Number648492
Brand Family Calbiochem®
SynonymsPhenanthren-9-ol, 9-Hydroxyphenanthrene
References
ReferencesGrand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.
Simard, C., 2012. Brit. Journ. Pharm.165, 2354.
Product Information
CAS number484-17-3
FormBrown solid
Hill FormulaC₁₄H₁₀O
Chemical formulaC₁₄H₁₀O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
648492-50MGCN 04055977185072

Documentation

TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem 分析证书

标题批号
648492

参考

参考信息概述
Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.
Simard, C., 2012. Brit. Journ. Pharm.165, 2354.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-July-2012 JSW
SynonymsPhenanthren-9-ol, 9-Hydroxyphenanthrene
DescriptionA cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number484-17-3
Chemical formulaC₁₄H₁₀O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesGrand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.
Simard, C., 2012. Brit. Journ. Pharm.165, 2354.