648490 Sigma-AldrichTRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem
The TRPC3 Channel Inhibitor, Pyr3, also referenced under CAS 1160514-60-2, controls the biological activity of TRPC3 Channel. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> The TRPC3 Channel Inhibitor, Pyr3, also referenced under CAS 1160514-60-2, controls the biological activity of TRPC3 Channel. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, CRAC Channel Inhibitor II, SB-360475
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 1160514-60-2 | C₁₆H₁₁Cl₃F₃N₃O₃ |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
|---|---|---|---|
| 648490-10MGCN | 塑胶安瓿;塑胶针药瓶 | 10 mg |
| Description | |
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| Overview | A cell-permeable pyrazole that acts as an equally potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 540 nM by Fura-2; peak current density pA/pF = -1.45 and -7.50, respectively, with or without 3 µM BTP2/Pyr3 by whole cell clamp) and the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) in TRPC3-expressing HEK293 cells (IC50 = 540 nM; by Fura-2; pA/pF = -2.27 and -18.50, respectively, with or without 3 µM BTP2/Pyr3). Pyr3 is also demonstrated to alleviate pressure overload-induced cardiac hypertrophy following TAC (transverse aortic constriction) operation in mice (0.1 mg/kg/day via i.p. osmotic pump) in vivo. A great complement to Pyr 2 (Cat. No. 203890), Pyr6, and Pyr10 in Ca2+ signaling studies. |
| Catalogue Number | 648490 |
| Brand Family | Calbiochem® |
| Synonyms | Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, CRAC Channel Inhibitor II, SB-360475 |
| References | |
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| References | Schleifier, H., et al. 2012. Br J Pharmacol In Press Kiyonaka, S., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 5400. |
| Product Information | |
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| CAS number | 1160514-60-2 |
| Form | White to beige solid |
| Hill Formula | C₁₆H₁₁Cl₃F₃N₃O₃ |
| Chemical formula | C₁₆H₁₁Cl₃F₃N₃O₃ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 648490-10MGCN | 04055977185065 |
Documentation
TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem MSDS
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TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem 分析证书
| 标题 | 批号 |
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| 648490 |
参考
| 参考信息概述 |
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| Schleifier, H., et al. 2012. Br J Pharmacol In Press Kiyonaka, S., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 5400. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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