Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

CC1062 TIMP-1, recombinant, active human

TIMP-1, recombinant, active human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Inhibits Activity/Function UniProt Number: P01033 Entrez Gene Number: NM_003254.2
CC1062
5 µg  5 μg/vial
Purchase on Sigma-Aldrich

概述

Replacement Information
Description
Catalogue NumberCC1062
ReplacesCC1063
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionTIMP-1, recombinant, active human
OverviewHuman TIMP-1, isolated from CHO cells transfected with human TIMP-1 cDNA. A single band at 29kDa is noted by SDS-PAGE.
References
Product Information
HS Code3502 90 90
PresentationPurified protein in 10 mM Sodium Phosphate, pH 7.3, 0.15M NaCl.
Quality LevelMQ100
Applications
Key Applications
  • Inhibits Activity/Function
Biological Information
Concentrationvaries by lot
Specific ActivityBIOLOGICAL ACTIVITY: <br /><br />IC50=1.38 x 10E-9M (versus 6.7 x 10E-9 M MMP-1). [Nagai, Y, (1984) Jpn. Jp. Inflam. 4:123-130]
Entrez Gene Number
Entrez Gene SummaryThis gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Gene Symbol
  • TIMP1
  • TIMP
  • FLJ90373
  • CLGI
  • EPA
  • EPO
  • TIMP-1
  • HCI
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P01033 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
SIZE: 207 amino acids; 23171 Da
SUBCELLULAR LOCATION: Secreted.
PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds.
SIMILARITY: SwissProt: P01033 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Availability by Geography
  • This product is not available for sale in Japan.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Manufactured by Daiichi Fine Chemical Co., Ltd
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size5 µg
Material Package5 μg/vial
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
CC1062 04053252678004