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567731 Sigma-AldrichSphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem

The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl, SK Inhibitor I

Primary Target: GST-hsk

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1177741-83-1	C₁₅H₁₁ClN₂OS • HCl

Products

产品目录编号	包装	数量 / 包装
567731-10MGCN	塑胶安瓿;塑胶针药瓶	10 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable disubstituted thiazole compound that displays anti-tumor properties. Acts as a potent, substrate competitive, reversible, and highly specific inhibitor of sphingosine kinase (IC₅₀ = 0.5 µM for GST-hSK). Does not affect the kinase activity of hERK2, hPI3K, or PKCα even at concentrations as high as 60 µM. Induces apoptosis in human cancer cells that express the drug transport proteins Pgp or MRP1 (IC₅₀ = ~ 1-5 µM) through inhibiting sphingosine-1-phosphate production.
Catalogue Number	567731
Brand Family	Calbiochem®
Synonyms	2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl, SK Inhibitor I

References
References	French, K.J., et al. 2003. Cancer Res. 63, 5962.

Product Information
CAS number	1177741-83-1
ATP Competitive	Y
Form	White solid
Hill Formula	C₁₅H₁₁ClN₂OS • HCl
Chemical formula	C₁₅H₁₁ClN₂OS • HCl
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	GST-hsk
Primary Target IC<sub>50</sub>	0.5 µM for GST-hSK
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
567731-10MGCN	07790788051686

Documentation

Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem 分析证书

标题	批号
567731	输入批号

参考

参考信息概述
French, K.J., et al. 2003. Cancer Res. 63, 5962.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-April-2011 RFH
Synonyms	2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl, SK Inhibitor I
Description	A cell-permeable, potent non-ATP-competitive, reversible, and specific inhibitor of sphingosine kinase (IC₅₀ = 500 nM for GST-hSK) that also exhibits anti-tumor properties. Does not affect the kinase activity of hERK2, hPI3 K, or PKC_α at cocentrations as high as 60 µM. Shown to induce apoptosis in human cancer cells that express the drug transport proteins Pgp or MRP1 (IC₅₀ ~1-5 µM) by inhibiting sphingosine-1-phosphate production.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1177741-83-1
Chemical formula	C₁₅H₁₁ClN₂OS • HCl
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	French, K.J., et al. 2003. Cancer Res. 63, 5962.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Sphingosine Kinase Inhibitors

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