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567630 Sodium Salicylate - CAS 54-21-7 - Calbiochem

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.

Sodium Salicylate - CAS 54-21-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Salicylic Acid, Na, NaSal

Primary Target: TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
567630
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
54-21-7C₇H₅O₃ · Na

Products

产品目录编号包装 数量 / 包装
567630-5GMCN 玻璃瓶 5 gm
Description
OverviewA cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
Catalogue Number567630
Brand Family Calbiochem®
SynonymsSalicylic Acid, Na, NaSal
References
ReferencesSchwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
Product Information
CAS number54-21-7
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₇H₅O₃ · Na
Chemical formulaC₇H₅O₃ · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
Purity≥98% by titration
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSVO5075000
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 24/25

Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
567630-5GMCN 04055977266825

Documentation

Sodium Salicylate - CAS 54-21-7 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Sodium Salicylate - CAS 54-21-7 - Calbiochem 分析证书

标题批号
567630

参考

参考信息概述
Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2008 RFH
SynonymsSalicylic Acid, Na, NaSal
DescriptionA non-steroidal, anti-inflammatory drug that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number54-21-7
RTECSVO5075000
Chemical formulaC₇H₅O₃ · Na
Structure formulaStructure formula
Purity≥98% by titration
SolubilityEthanol or H₂O (50 mg/ml)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
Merck USA index14, 8332
ReferencesSchwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.