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567616 Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem

Sodium 4-Phenylbutyrate, CAS 1716-12-7, is a novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: SPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BDK Inhibitor I, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I

Primary Target: Anti-neoplastic agent
567616
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

CAS #Empirical Formula
1716-12-7C₁₀H₁₁O₂Na

Products

产品目录编号包装 数量 / 包装
567616-100MGCN 塑胶安瓿;塑胶针药瓶 100 mg
Description
OverviewA novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Increases fetal hemoglobin production in vitro and in vivo.
Catalogue Number567616
Brand Family Calbiochem®
SynonymsSPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BDK Inhibitor I, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I
References
ReferencesTso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 9728.
Ozcan, U., et al. 2006. Science 313, 1137.
Carducci, M.A., et al. 2001. Clin. Cancer Res. 7, 3047.
Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol. 278, C259.
Lea, M.A., et al. 1999. Anticancer Res. 19, 1971.
Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211.
Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457.
Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659.
Collins, A.F., et al. 1995. Blood 85, 43.
Lea, M.A., et al. 1995. Anticancer Res. 15, 879.
Figg, W.D., et al. 1994. Anticancer Drugs 5, 336.
Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335.
Product Information
CAS number1716-12-7
ATP CompetitiveN
FormWhite to slightly yellow solid
Hill FormulaC₁₀H₁₁O₂Na
Chemical formulaC₁₀H₁₁O₂Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSodium 4-Phenylbutyrate, CAS 1716-12-7, is a novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.
Biological Information
Primary TargetAnti-neoplastic agent
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
567616-100MGCN 04055977266818

Documentation

Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem 分析证书

标题批号
567616

参考

参考信息概述
Tso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 9728.
Ozcan, U., et al. 2006. Science 313, 1137.
Carducci, M.A., et al. 2001. Clin. Cancer Res. 7, 3047.
Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol. 278, C259.
Lea, M.A., et al. 1999. Anticancer Res. 19, 1971.
Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211.
Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457.
Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659.
Collins, A.F., et al. 1995. Blood 85, 43.
Lea, M.A., et al. 1995. Anticancer Res. 15, 879.
Figg, W.D., et al. 1994. Anticancer Drugs 5, 336.
Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-January-2024 JSW
SynonymsSPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BDK Inhibitor I, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I
DescriptionAn antineoplastic agent that demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell lines. Acts as an inducer of tumor cytostasis and differentiation as well as of peroxisomal proliferation. A more effective inhibitor of histone deacetylase and inducer of histone acetylation than its structural analogs including 2- and 3-phenylbutyrate. Acts as a transcriptional regulator and improve the targeting of δF508-CFTR (cystic fibrosis transmembrane regulator) for ubiquitination and degradation by reducing the expression of HSC70 in epithelial cells. Also, reported to increase fetal hemoglobin production in vitro and in vivo.
FormWhite to slightly yellow solid
CAS number1716-12-7
Chemical formulaC₁₀H₁₁O₂Na
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (10 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 9728.
Ozcan, U., et al. 2006. Science 313, 1137.
Carducci, M.A., et al. 2001. Clin. Cancer Res. 7, 3047.
Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol. 278, C259.
Lea, M.A., et al. 1999. Anticancer Res. 19, 1971.
Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211.
Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457.
Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659.
Collins, A.F., et al. 1995. Blood 85, 43.
Lea, M.A., et al. 1995. Anticancer Res. 15, 879.
Figg, W.D., et al. 1994. Anticancer Drugs 5, 336.
Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335.