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567375 Smac-N7 Peptide, Cell-Permeable - Calbiochem

The Smac-N7 peptide is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: AVPIAQKPRQIKIWFQNRRMKWKK

Primary Target: Promotes procaspase-3 activation
567375
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概述

Replacement Information

重要规格表

Empirical Formula
C₁₄₂H₂₃₂N₄₄O₂₉S

Products

产品目录编号包装 数量 / 包装
567375-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
OverviewThe Smac-N7 peptide (Cat. No. 567370) is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.
Catalogue Number567375
Brand Family Calbiochem®
SynonymsAVPIAQKPRQIKIWFQNRRMKWKK
References
ReferencesSrinivasula, S.M., et al. 2001. Nature 410, 112.
Chai, J., et al. 2000. Nature 406, 855.
Liu, Z., et al. 2000. Nature 408, 1004.
Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₄₂H₂₃₂N₄₄O₂₉S
Chemical formulaC₁₄₂H₂₃₂N₄₄O₂₉S
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetPromotes procaspase-3 activation
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Ala-Val-Pro-Ile-Ala-Gln-Lys-Pro-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
567375-1MGCN 07790788051594

Documentation

Smac-N7 Peptide, Cell-Permeable - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Smac-N7 Peptide, Cell-Permeable - Calbiochem 分析证书

标题批号
567375

参考

参考信息概述
Srinivasula, S.M., et al. 2001. Nature 410, 112.
Chai, J., et al. 2000. Nature 406, 855.
Liu, Z., et al. 2000. Nature 408, 1004.
Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-September-2008 RFH
SynonymsAVPIAQKPRQIKIWFQNRRMKWKK
DescriptionThe Smac-N7 peptide (Cat. No. 567370) where the lysine carboxy terminal is linked to the arginine of Antennapedia homeodomain 16-mer peptide (underlined) via a proline linker to make it cell-permeable. Smac-N7 peptide contains the N-terminal seven residues of Smac and promotes the activation of procaspase-3 (~10 µM). Also, promotes the catalytic activity of caspase-9 in the presence of XIAP.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄₂H₂₃₂N₄₄O₂₉S
Peptide SequenceH-Ala-Val-Pro-Ile-Ala-Gln-Lys-Pro-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSrinivasula, S.M., et al. 2001. Nature 410, 112.
Chai, J., et al. 2000. Nature 406, 855.
Liu, Z., et al. 2000. Nature 408, 1004.
Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.