Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

567021 Simvastatin, Sodium Salt - Calbiochem

567021
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

Empirical Formula
C₂₅H₃₉O₆ • Na

Products

产品目录编号包装 数量 / 包装
567021-50MGCN 玻璃瓶 50 mg
567021-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free preparations. Also available as a 10 mM solution in H2O (Cat. No. 567022).
Catalogue Number567021
Brand Family Calbiochem®
SynonymsL-Type Calcium Channel Blocker VI
References
ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Product Information
ATP CompetitiveN
FormBeige solid
Hill FormulaC₂₅H₃₉O₆ • Na
Chemical formulaC₂₅H₃₉O₆ • Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
567021-50MGCN 04055977267112
567021-5MGCN 07790788051587

Documentation

Simvastatin, Sodium Salt - Calbiochem 分析证书

标题批号
567021

参考

参考信息概述
Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-October-2015 JSW
SynonymsL-Type Calcium Channel Blocker VI
DescriptionCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an active form; no treatment with NaOH in ethanol is required for its activation.
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₅H₃₉O₆ • Na
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml), Ethanol (25 mg/ml), or H₂O (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.