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566313 SIRT1 Activator II - CAS 374922-43-7 - Calbiochem

The SIRT1 Activator II, also referenced under CAS 374922-43-7, modulates the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 3-(Benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[4,5-b]quinoxalin-2-amine , CAY10602, SIRT1 Activator II

566313
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
374922-43-7C₂₂H₁₅FN₄O₂S

Products

产品目录编号包装 数量 / 包装
566313-10MGCN 玻璃瓶 10 mg
Description
OverviewA cell-permeable pyrroloquinoxaline compound that acts as a reversible SIRT1 activator (10 µM causes ~2.3-fold fluorescent enhancement in a fluorescent assay using hrSIRT1) and enhances fat mobilization in fully differentiated 3T3L1 fibroblasts. Shown to inhibit LPS-induced TNF-α release in THP-1 cells by ~10-fold more potent than resveratrol (Cat. No. 554325).
Catalogue Number566313
Brand Family Calbiochem®
Synonyms3-(Benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[4,5-b]quinoxalin-2-amine , CAY10602, SIRT1 Activator II
References
ReferencesLavu, S., et al. 2008. Nat. Rev. Drug Discov. 7, 841.
Nayagam, V.M., et al. 2006. J. Biomol. Screen. 11, 959.
Product Information
CAS number374922-43-7
FormOff-white powder
Hill FormulaC₂₂H₁₅FN₄O₂S
Chemical formulaC₂₂H₁₅FN₄O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
566313-10MGCN 04055977191363

Documentation

SIRT1 Activator II - CAS 374922-43-7 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

SIRT1 Activator II - CAS 374922-43-7 - Calbiochem 分析证书

标题批号
566313

参考

参考信息概述
Lavu, S., et al. 2008. Nat. Rev. Drug Discov. 7, 841.
Nayagam, V.M., et al. 2006. J. Biomol. Screen. 11, 959.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-November-2021 JSW
Synonyms3-(Benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[4,5-b]quinoxalin-2-amine , CAY10602, SIRT1 Activator II
DescriptionA cell-permeable pyrroloquinoxaline compound that acts as a reversible SIRT1 activator (10 µM causes ~2.3-fold fluorescent enhancement in a fluorescent assay using hrSIRT1) and enhances fat mobilization in fully differentiated 3T3L1 fibroblasts. Shown to inhibit LPS-induced TNF-α release in THP-1 cells by ~10-fold more potent than resveratrol (Cat. No. 554325).
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number374922-43-7
Chemical formulaC₂₂H₁₅FN₄O₂S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLavu, S., et al. 2008. Nat. Rev. Drug Discov. 7, 841.
Nayagam, V.M., et al. 2006. J. Biomol. Screen. 11, 959.