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557525 Ro-32-0432 - CAS 145333-02-4 - Calbiochem

A selective cell-permeable protein kinase C inhibitor.

Ro-32-0432 - CAS 145333-02-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride

Primary Target: PKCα
557525
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
145333-02-4C₂₈H₂₈N₄O₂ · HCl

Products

产品目录编号包装 数量 / 包装
557525-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
OverviewA selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over PKCε (IC50 = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number557525
Brand Family Calbiochem®
Synonyms2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
References
ReferencesBirchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
Product Information
CAS number145333-02-4
ATP CompetitiveN
FormRed solid
Hill FormulaC₂₈H₂₈N₄O₂ · HCl
Chemical formulaC₂₈H₂₈N₄O₂ · HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKCα
Primary Target IC<sub>50</sub>9 nM, 28 nM, 108 nM, against PKCα, PKCβI, and PKCε, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
557525-1MGCN 04055977193008

Documentation

Ro-32-0432 - CAS 145333-02-4 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Ro-32-0432 - CAS 145333-02-4 - Calbiochem 分析证书

标题批号
557525

参考

参考信息概述
Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.

引用

标题
  • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.
    		•
    数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision22-October-2014 JSW
    Synonyms2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
    DescriptionA selective cell-permeable protein kinase C inhibitor. Displays about a 10-fold greater selectivity for PKCα (IC50 = 9 nM) and a 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over PKCε (IC50 = 108 nM). Also prevents T-cell driven chronic inflammatory responses in vivo.
    FormRed solid
    CAS number145333-02-4
    Chemical formulaC₂₈H₂₈N₄O₂ · HCl
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage Protect from light
    +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
    Toxicity Standard Handling
    ReferencesBirchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922.
    Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
    Citation
  • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.
    		•