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			96-Well Plate

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553031 Sigma-AldrichRAGE Antagonist Peptide, RAP - Calbiochem

The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.

RAGE Antagonist Peptide, RAP - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: ELKVLMEKEL

Primary Target: RAGE

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₅₇H₁₀₁N₁₃O₁₇S

Products

产品目录编号	包装	数量 / 包装
553031-10MGCN	玻璃瓶	10 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
Catalogue Number	553031
Brand Family	Calbiochem®
Synonyms	ELKVLMEKEL

References
References	Arumugam, T., et al. 2012. Clin Cancer Res. 18, 4356.

Product Information
Form	White powder
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₅₇H₁₀₁N₁₃O₁₇S
Reversible	Y
Quality Level	MQ200

Applications

Biological Information
Primary Target	RAGE
Primary Target IC<sub>50</sub>	2 µ
Purity	≥95% by HPLC

Physicochemical Information
Peptide Sequence	Ac-ELKVLMEKEL-NH2

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
553031-10MGCN	04055977193473

Documentation

RAGE Antagonist Peptide, RAP - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

RAGE Antagonist Peptide, RAP - Calbiochem 分析证书

标题	批号
553031	输入批号

参考

参考信息概述
Arumugam, T., et al. 2012. Clin Cancer Res. 18, 4356.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-October-2012 JSW
Synonyms	ELKVLMEKEL
Description	An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
Form	White powder
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Peptide Sequence	Ac-ELKVLMEKEL-NH2
Purity	≥95% by HPLC
Solubility	H₂O (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Arumugam, T., et al. 2012. Clin Cancer Res. 18, 4356.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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