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553018 RAF Kinase Inhibitor VII

RAF Kinase Inhibitor VII MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 1-(4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

553018
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概述

Replacement Information

Products

产品目录编号包装 数量 / 包装
553018-5MGCN 玻璃瓶 5 mg
Description
OverviewA cell-permeable imidazopyridinyl-urea compound that acts as a potent inhibitor against B-RafV600E activity (IC50 = 1 nM) by targeting its ATP-binding pocket and the adjacent lipophilic allosteric site accessible only when the enzyme is in its inactive DFG-out conformation. Reported to effectively inhibit RafV600E-dependent ERK phosphorylation (IC50 = 610 nM) and growth of human melanoma WM266.4 cells (GI50 = 470 nM).
Catalogue Number553018
Brand Family Calbiochem®
Synonyms1-(4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
References
ReferencesMenard, D., et al. 2009. J. Med. Chem. 52, 3881.
Product Information
CAS number884339-61-1
FormCarmel powder
Hill FormulaC₂₁H₁₅ClF₃N₅O₃S
Chemical formulaC₂₁H₁₅ClF₃N₅O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
553018-5MGCN 04055977193459

Documentation

RAF Kinase Inhibitor VII MSDS

职位

物料安全数据表 (MSDS) 

参考

参考信息概述
Menard, D., et al. 2009. J. Med. Chem. 52, 3881.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-April-2012 JSW
Synonyms1-(4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
DescriptionA cell-permeable imidazopyridinyl-urea compound that acts as a potent inhibitor against B-RafV600E activity (IC50 = 1 nM) by targeting its ATP-binding pocket and the adjacent lipophilic allosteric site accessible only when the enzyme is in its inactive DFG-out conformation. Reported to effectively inhibit RafV600E-dependent ERK phosphorylation (IC50 = 610 nM) and growth of human melanoma WM266.4 cells (GI50 = 470 nM).
FormCarmel powder
Intert gas (Yes/No) Packaged under inert gas
CAS number884339-61-1
Chemical formulaC₂₁H₁₅ClF₃N₅O₃S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesMenard, D., et al. 2009. J. Med. Chem. 52, 3881.