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553510 RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem

553510
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概述

重要规格表

CAS #Empirical Formula
312756-74-4C₂₀H₁₆Br₂N₂O₃S

Products

产品目录编号包装 数量 / 包装
553510-10MGCN 塑胶安瓿;塑胶针药瓶 10 mg
Description
OverviewA cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis. Although RS-1 enhances hRAD51 filament formation on ssDNA with or without the cofactor NTP, active filaments and recombinase activity are only induced in the presence of ATP or AMP-PNP, but not with ADP or no cofactors. Shown to promote resistance of primary human neonatal dermal fibroblasts to Cisplatin- (Cat. No. 232120) induced death in a dose-dependent manner. RS-1 is inactive toward related DNA strand exchange proteins scRAD5 and scDMC1 of yeast origin or E. coli RedA.This HDR (homology-directed repair) enhancer, is shown to significantly increase both Cas9 & TALEN-mediated knock-in efficiencies.
Catalogue Number553510
Brand Family Calbiochem®
Synonyms3-((Benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)-benzamide, RS-1
References
ReferencesSong, J., et al. 2016. Nat. Comm., In Press.
Jayathilaka, K., et al. 2008. Proc. Natl. Acad. Sci. USA. 105, 15848.
Product Information
CAS number312756-74-4
FormLight beige solid
Hill FormulaC₂₀H₁₆Br₂N₂O₃S
Chemical formulaC₂₀H₁₆Br₂N₂O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
产品目录编号 GTIN
553510-10MGCN 04055977193695