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52332 Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem

52332
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
329-98-6C₇H₇FO₂S

Products

产品目录编号包装 数量 / 包装
52332-1GMCN 铝滚桶 1 gm
52332-25GMCN 纤维箱 25 gm
52332-5GMCN 玻璃瓶 5 gm
Description
OverviewIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).
Catalogue Number52332
Brand Family Calbiochem®
SynonymsBenzylsulfonyl Fluoride, PMSF
References
ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
Product Information
CAS number329-98-6
ATP CompetitiveN
FormWhite to off-white crystalline solid
Hill FormulaC₇H₇FO₂S
Chemical formulaC₇H₇FO₂S
Reconstitutiont½ = 1 hour at pH 7.5. Effective concentration: 50 μM.
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary Targetserine proteases
Purity≥99% by GC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXT8040000
Safety Information
R PhraseR: 34

Causes burns.
S PhraseS: 26-36/37/39-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Corrosive
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
52332-1GMCN 07790788051044
52332-25GMCN 04055977271508
52332-5GMCN 04055977271515

Documentation

Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem 分析证书

标题批号
52332

参考

参考信息概述
Seitz, R., et al. 1993. Int. J. Cancer 53, 514.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
Chang, C.T., et al. 1992. Biochem. Int. 28, 707.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题
  • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.
  • 数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision19-August-2008 RFH
    SynonymsBenzylsulfonyl Fluoride, PMSF
    DescriptionIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.
    FormWhite to off-white crystalline solid
    CAS number329-98-6
    RTECSXT8040000
    Chemical formulaC₇H₇FO₂S
    Structure formulaStructure formula
    Purity≥99% by GC
    SolubilityEthanol, isopropanol, or methanol
    Storage Protect from moisture
    +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
    Toxicity Corrosive
    ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
    Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
    Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
    Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
    Citation
  • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.