Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

516481 Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem

Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid

Primary Target: cathepsin D
516481
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

CAS #Empirical Formula
26305-03-3C₃₄H₆₃N₅O₉

Products

产品目录编号包装 数量 / 包装
516481-100MGCN 塑胶安瓿;塑胶针药瓶 100 mg
516481-25MGCN 塑胶安瓿;塑胶针药瓶 25 mg
516481-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cell lines. Also available as a 25 mM solution in DMSO (Cat. No. 508437).
Effective concentration: 1.0 µM.
Catalogue Number516481
Brand Family Calbiochem®
SynonymsIva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
References
ReferencesIsahara, K., et al. 1999. Neuroscience 91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
Carraway, R.E., et al. 1991. Peptides 12, 107.
Eid, M., et al. 1981. Biochem. J. 197, 465.
Umezawa, H., et al. 1970. J. Antibiot. 23, 259.
Product Information
CAS number26305-03-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₄H₆₃N₅O₉
Chemical formulaC₃₄H₆₃N₅O₉
Optical rotationOptical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C).
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin D
Primary Target IC<sub>50</sub>EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSSC6155000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
516481-100MGCN 04055977198812
516481-25MGCN 07790788055837
516481-5MGCN 04055977198836

Documentation

Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem 分析证书

标题批号
516481

参考

参考信息概述
Isahara, K., et al. 1999. Neuroscience 91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
Carraway, R.E., et al. 1991. Peptides 12, 107.
Eid, M., et al. 1981. Biochem. J. 197, 465.
Umezawa, H., et al. 1970. J. Antibiot. 23, 259.

小册子

标题
Western Blotting Tools

技术信息

标题
Protein Blotting Handbook: 6th Edition
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-October-2013 JSW
SynonymsIva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
DescriptionA reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cells. Effective concentration: 1 µM.
FormWhite solid
Recommended reaction conditions
Activity:
Activity is measured by inhibition of pepsin. 1 U corresponds to the amount of inhibitor that reduces the activity of pepsin by 1 U (1 U of enzyme corresponds to the amount of enzyme that results in the increases the absorbance at 280 nm by 0.001 per min at pH 2.0, 37°C.)
CAS number26305-03-3
RTECSSC6155000
Chemical formulaC₃₄H₆₃N₅O₉
Purity≥98% by HPLC
SolubilityDMSO (1 mg/ml) or Methanol (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 7147
ReferencesIsahara, K., et al. 1999. Neuroscience 91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
Carraway, R.E., et al. 1991. Peptides 12, 107.
Eid, M., et al. 1981. Biochem. J. 197, 465.
Umezawa, H., et al. 1970. J. Antibiot. 23, 259.