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580556 Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem

A semi-synthetic form of Paclitaxel having no contamination by natural taxanes. Also has reduced levels of epimerization products as contaminants.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Promotes assembly of microtubules and inhibits tubulin disassembly.
580556
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
33069-62-4C₄₇H₅₁NO₁₄

Products

产品目录编号包装 数量 / 包装
580556-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA semi-synthetic form of Paclitaxel (Cat. No. 580555) having no contamination by natural taxanes. Also has reduced levels of epimerization products as contaminants.
Catalogue Number580556
Brand Family Calbiochem®
References
ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo 8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science 248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
Product Information
CAS number33069-62-4
ATP CompetitiveN
FormCrystalline solid
Hill FormulaC₄₇H₅₁NO₁₄
Chemical formulaC₄₇H₅₁NO₁₄
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetPromotes assembly of microtubules and inhibits tubulin disassembly.
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDA8340700
Safety Information
R PhraseR: 37/38-41-46-60

Irritating to respiratory system and skin.
Risk of serious damage to eyes.
May cause heritable genetic damage.
May impair fertility.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
580556-5MGCN 04055977265538

Documentation

Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Paclitaxel, Semi-Synthetic - CAS 33069-62-4 - Calbiochem 分析证书

标题批号
580556

参考

参考信息概述
Derry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo 8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science 248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-May-2011 JSW
DescriptionA semi-synthetically derived form of Paclitaxel (TAXOL®, Cat. No. 580555) having no contamination of natural taxanes. Also has less epimerization products as contaminants. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
FormCrystalline solid
CAS number33069-62-4
RTECSDA8340700
Chemical formulaC₄₇H₅₁NO₁₄
Purity≥97% by HPLC
SolubilityDMSO or methanol
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 6982
ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo 8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science 248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.