476495 Sigma-AldrichPKD Inhibitor, CID755673 - CAS 521937-07-5 - Calbiochem
The PKD Inhibitor, CID755673, also referenced under CAS 521937-07-5, controls the biological activity of PKD. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The PKD Inhibitor, CID755673, also referenced under CAS 521937-07-5, controls the biological activity of PKD. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: 7-Hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one, PKCμ Inhibitor
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 521937-07-5 | C₁₂H₁₁NO₃ |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
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| 476495-10MGCN | 10 mg |
| Description | |
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| Overview | A cell-permeable benzoxoloazepinolone compound that effectively inhibits syntide-2 (Cat. No. 05-23-4910) phosphorylation by all three PKD/PKCµ isoforms 1, 2, & 3 (IC50 = 182, 280, and 227 nM, respectively), while exhibiting ≥30-fold less potency towards Cdk activating kinase, Plk1, CaMKIIα, as well as 44 other kinases, 33 of which are not significantly inhibited even at concentrations as high as 10 µM, including Akt1/2 and PKCα/β/δ/ζ. Shown to block PMA- (Cat. No. 524400) induced PKD1 phosphorylation on Ser742 and Ser916 in LNCaP cells, PMA-induced HCAS5 nuclear export in HeLa cells, as well as other PKD-mediated cellular responses. The mode of inhibition is demonstrated not to be ATP-competitive in nature. Also reported to inhibit MAPKAPK2, GSK-3β, CKIδ, MK5 (PRAK), CDK2, and Erk1 kinase activity at much elevated concentrations (% inhibition by 10 µM inhibitor = 95, 86, 82, 75, 71, and 50, respectively). |
| Catalogue Number | 476495 |
| Brand Family | Calbiochem® |
| Synonyms | 7-Hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one, PKCμ Inhibitor |
| References | |
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| References | LaValle, C.R., et al. 2010. BMC Chemical Biology 10, 5. Sharlow, E.R., et al. 2008. J. Biol. Chem. 283, 33516. |
| Product Information | |
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| CAS number | 521937-07-5 |
| Form | Brown solid |
| Hill Formula | C₁₂H₁₁NO₃ |
| Chemical formula | C₁₂H₁₁NO₃ |
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| Quality Level | MQ100 |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 476495-10MGCN | 04055977183849 |
Documentation
PKD Inhibitor, CID755673 - CAS 521937-07-5 - Calbiochem MSDS
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PKD Inhibitor, CID755673 - CAS 521937-07-5 - Calbiochem 分析证书
| 标题 | 批号 |
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| 476495 |
参考
| 参考信息概述 |
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| LaValle, C.R., et al. 2010. BMC Chemical Biology 10, 5. Sharlow, E.R., et al. 2008. J. Biol. Chem. 283, 33516. |