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521233 PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409

Primary Target: PDGFR Tyrosine Kinase
521233
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
627518-40-5C₁₈H₁₆FN₃O₂

Products

产品目录编号包装 数量 / 包装
521233-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
OverviewA cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 < 33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, > 10 µM, > 10 µM, 45.8 µM and > 100 µM, respectively).
Catalogue Number521233
Brand Family Calbiochem®
Synonyms3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
References
ReferencesHo, C.Y., et al. 2005. J. Med. Chem. 48, 8163.
Product Information
CAS number627518-40-5
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₁₈H₁₆FN₃O₂
Chemical formulaC₁₈H₁₆FN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDGFR Tyrosine Kinase
Primary Target IC<sub>50</sub>4.2 nM and 45 nM for -β and -α form of PDGFR, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
521233-1MGCN 04055977271379

Documentation

PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem 分析证书

标题批号
521233

参考

参考信息概述
Ho, C.Y., et al. 2005. J. Med. Chem. 48, 8163.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-August-2008 RFH
Synonyms3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
DescriptionA cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 <33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, >10 µM, >10 µM, 45.8 µM and >100 µM, respectively).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number627518-40-5
Chemical formulaC₁₈H₁₆FN₃O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesHo, C.Y., et al. 2005. J. Med. Chem. 48, 8163.