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505758 Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Purinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP

Primary Target: P2X₇
505758
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
71997-40-5C₁₀H₁₄N₅O₁₃P₃

Products

产品目录编号包装 数量 / 包装
5.05758.0001.1753 玻璃瓶 25 mg
Description
OverviewA 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
Catalogue Number505758
Brand Family Calbiochem®
SynonymsPurinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
References
ReferencesVergani, A., et al. 2013. Diabetes 62, 1665.
DellʹAntonio, G., et al. 2002. Arthritis Rheum. 46, 3378.
Wiley, J.S., et al. 1994. Br. J. Pharmacol. 112, 946.
Murgia, M., et al. 1992. J. Biol. Chem. 268, 8199.
Product Information
CAS number71997-40-5
FormWhite powder
Hill FormulaC₁₀H₁₄N₅O₁₃P₃
Chemical formulaC₁₀H₁₄N₅O₁₃P₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetP2X₇
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
5.05758.0001.1753 04055977243482

Documentation

Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

参考

参考信息概述
Vergani, A., et al. 2013. Diabetes 62, 1665.
DellʹAntonio, G., et al. 2002. Arthritis Rheum. 46, 3378.
Wiley, J.S., et al. 1994. Br. J. Pharmacol. 112, 946.
Murgia, M., et al. 1992. J. Biol. Chem. 268, 8199.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2013 JSW
SynonymsPurinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
DescriptionA 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
FormWhite powder
CAS number71997-40-5
Chemical formulaC₁₀H₁₄N₅O₁₃P₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityH₂O (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesVergani, A., et al. 2013. Diabetes 62, 1665.
DellʹAntonio, G., et al. 2002. Arthritis Rheum. 46, 3378.
Wiley, J.S., et al. 1994. Br. J. Pharmacol. 112, 946.
Murgia, M., et al. 1992. J. Biol. Chem. 268, 8199.