NovaSyn® TG resins for solid phase peptide synthesis

NovaSyn® TG and NovaSyn® TG^R resins are based on a composite of low cross-linked hydroxyethylpolystyrene and polyethylene glycol which has been terminally functionalized. NovaSyn® TG resin is available as 90 µm and 130 µm beads. These resins are suitable for both continuous flow and batch peptide synthesis. The NovaSyn® TG^R resins have been specifically designed for the synthesis of long and challenging sequences.

They have excellent physical stability in flow systems, are resistant to abrasion and mechanical pressure, and offer improved chemical efficiency. High flow rates have even been reported to increase the acylation and deprotection rates of NovaSyn® TG resins¹.

1. a) W. Rapp et al. in “Peptides 1988, Proc. 20st European Peptide Symposium”, G. Jung & E. Bayer (Eds.), Walter de Gruyter, Berlin, 1989, pp. 199; b) W. Rapp, et al. in “Innovation and Perspectives in Solid Phase Synthesis”, R.Epton (Ed.), SPCC (UK) Ltd, Birmingham, 1990, pp. 205; c) L. Zhang et al. in “Peptides 1990, Proc. 21st European Peptide Symposium”, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp. 196; d) E. Bayer (1991) Angew. Chem. Int. Ed. Engl., 30, 113; e) E. Bayer et al. in “Peptides Structure and Function”, V.J. Hubry & D.M. Rich (Eds.), Pierce Chemical Company, Rockford, 1983, pp. 87; f) W. Rapp and E. Bayer in “Polyethyleneglycol chemistry, Biochemical and Biomedical Applications”, J.Milton-Harris (Ed.), Plenum Press, 1992, pp. 325; g) W. Rapp, et al. in “Peptides 1994, Proc. 23rd European Peptide Symposium”, H. Maia (Ed.), ESCOM, Leiden, 1995, pp. 87.