NovaGel™ resins for peptide and organic synthesis

NovaGel™, also known as Champion resin, is a type of PEG-PS resin that has been designed to meet the requirements of chemists for resins of high substitution with broad solvent compatibility. It is prepared from a special high-swelling version of aminomethylated resin by partial derivatization with methyl-PEG₂₀₀₀-p-nitro-phenylcarbonate ^{1, 2}. This produces a resin containing approximately 48% PEG with a substitution of 0.5 mmol/g which is almost twice that of conventional PEG-PS supports. It swells in solvents of such widely different polarities as THF, DMF, acetonitrile and methanol, making it an excellent support for both peptide and organic synthesis.

The urethane linkage between the PEG and the base resin is stable to piperidine and TFA, ensuring minimal loss of PEG chains during synthesis. However, if leaching of PEG does occur, this does not result in loss of substitution as can be the case with other PEG-PS-based resins, because the linker is not attached to the end of the PEG chains.

The combination of high substitution and excellent swelling characteristics also makes NovaGel™-based supports very cost-effective for the solid phase peptide synthesis of medium-length peptides in large quantities.

1. J. H. Adams, et al. (1998) J. Org. Chem., 63, 3706.
2. D. Hudson, et al. (1999) in "Peptides 1998: Proceedings of the 25th Europ