480870 Sigma-AldrichNeurotrophin Antagonist, Y1036 - Calbiochem
The Neurotrophin Antagonist, Y1036 controls the biological activity of Neurotrophin. This small molecule/inhibitor is primarily used for Neuroscience applications.
More>> The Neurotrophin Antagonist, Y1036 controls the biological activity of Neurotrophin. This small molecule/inhibitor is primarily used for Neuroscience applications. Less<<Neurotrophin Antagonist, Y1036 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: 3-[4-Oxo-5-[[5-(4-sulfamoylphenyl)-2-furyl]methylene]-2-thioxo-thiazolidin-3-yl]propanoic acid
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概述
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重要规格表
| Empirical Formula |
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| C₁₇H₁₄N₂O₆S₃ |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
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| 480870-10MGCN | 玻璃瓶 | 10 mg |
| Description | |
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| Overview | A furyl-thioxothiazolidinone compound that binds both BDNF (Cat. No. 203702) and NGF (Cat. No. 480352) (KD = 3.5 and 3.0 µM, respectively) and prevents their interaction with cell surface receptors (IC50 against BDNF/p75NTR, BDNF/trkB, NGF/p75NTR, and NGF/trkA interaction = 6.2, 3.7, 5.7, and 8.8 µM, respectively, in PC12 cultures), while exhibiting no effect against the receptor binding of the non-neurotrophin growth factors EGF and PDGF. Y1036 at 40 µM is shown to inhibit trkA and trkB phosphorylation upon 40 pM BDNF and NGF treatment, respectively, as well as downstream Erk phosphorylation. Y1036 is also demonstrated to block BDNF- and NGF-induced neurite outgrowth in rat embryonic dorsal-root ganglions in a dose-dependent manner. |
| Catalogue Number | 480870 |
| Brand Family | Calbiochem® |
| Synonyms | 3-[4-Oxo-5-[[5-(4-sulfamoylphenyl)-2-furyl]methylene]-2-thioxo-thiazolidin-3-yl]propanoic acid |
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| References | Eibl, J.K., et al. 2009. J. Pharmacol. Exp. Ther. 332, 446. |
| Product Information | |
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| Form | Yellow solid |
| Hill Formula | C₁₇H₁₄N₂O₆S₃ |
| Chemical formula | C₁₇H₁₄N₂O₆S₃ |
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| Quality Level | MQ100 |
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| Purity | ≥90% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 480870-10MGCN | 04055977201482 |
Documentation
Neurotrophin Antagonist, Y1036 - Calbiochem MSDS
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Neurotrophin Antagonist, Y1036 - Calbiochem 分析证书
| 标题 | 批号 |
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| 480870 |
参考
| 参考信息概述 |
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| Eibl, J.K., et al. 2009. J. Pharmacol. Exp. Ther. 332, 446. |