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492030 NS 2028 - CAS 204326-43-2 - Calbiochem

Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase.

NS 2028 - CAS 204326-43-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one

Primary Target: basal soluble guanylyl cyclase
492030
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
204326-43-2C₉H₅BrN₂O₃

Products

产品目录编号包装 数量 / 包装
492030-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewPotent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
Catalogue Number492030
Brand Family Calbiochem®
Synonyms4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
References
ReferencesFleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.
Product Information
CAS number204326-43-2
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₉H₅BrN₂O₃
Chemical formulaC₉H₅BrN₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetbasal soluble guanylyl cyclase
Primary Target IC<sub>50</sub>30 nM for basal and 200 nM for NO-stimulated enzyme activity; 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum
Purity≥98% by NMR
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
492030-5MGCN 04055977273557

Documentation

NS 2028 - CAS 204326-43-2 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

NS 2028 - CAS 204326-43-2 - Calbiochem 分析证书

标题批号
492030

参考

参考信息概述
Fleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.

小册子

标题
Pathways and Biomarkers of Oxidative Stress
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
Synonyms4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
DescriptionPotent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
FormWhite to off-white solid
CAS number204326-43-2
Chemical formulaC₉H₅BrN₂O₃
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityDMSO (5 mg/ml), Ethanol (5 mg/ml), or CHCl₃ (1 mg/ml)
Storage Protect from moisture
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesFleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.