500526 Sigma-AldrichNOX Inhibitor VII, Thr101 - CAS 727664-79-1 - Calbiochem
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Primary Target:
blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: NADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one
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概述
重要规格表
| CAS # | Empirical Formula |
|---|---|
| 727664-79-1 | C₁₄H₁₀FNOS |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
|---|---|---|---|
| 5.00526.0001 | 玻璃瓶 | 25 mg |
| Description | |
|---|---|
| Overview | A cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phox bis-SH3 binding (IC50 = 4 vs. 0.3 µM) and NOX2 activity (IC50 = 4 vs. 0.6 µM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 µM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 500526 |
| Brand Family | Calbiochem® |
| Synonyms | NADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one |
| References | |
|---|---|
| References | Smith, S.M.E., et al. 2012. Chem. Biol. 19, 752. |
| Product Information | |
|---|---|
| CAS number | 727664-79-1 |
| Form | Light brown powder |
| Hill Formula | C₁₄H₁₀FNOS |
| Chemical formula | C₁₄H₁₀FNOS |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| 产品目录编号 | GTIN |
| 5.00526.0001 | 04055977244892 |