480403 Sigma-AldrichNFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem
The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
More>> The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: Inhibitor of NFAT-Calcineurin Association-6, INCA-6
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 3519-82-2 | C₂₀H₁₂O₂ |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
|---|---|---|---|
| 480403-5MGCN | 塑胶安瓿;塑胶针药瓶 | 5 mg |
| Description | |
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| Overview | A cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling. |
| Catalogue Number | 480403 |
| Brand Family | Calbiochem® |
| Synonyms | Inhibitor of NFAT-Calcineurin Association-6, INCA-6 |
| References | |
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| References | Roehrl, M.H.A., et al. 2004. Biochemistry 43, 16067. Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554. |
| Product Information | |
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| CAS number | 3519-82-2 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₂₀H₁₂O₂ |
| Chemical formula | C₂₀H₁₂O₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Calcineurin-NFAT |
| Primary Target IC<sub>50</sub> | Kd = 800 nM for calcineurin-NFAT |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 480403-5MGCN | 04055977201321 |
Documentation
NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem MSDS
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NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem 分析证书
| 标题 | 批号 |
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| 480403 |
参考
| 参考信息概述 |
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| Roehrl, M.H.A., et al. 2004. Biochemistry 43, 16067. Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554. |