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480415 NF023 - Calbiochem

A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go/Gi group (EC₅₀ ~ 300 nM).

NF023 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 8,8ʹ-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I

Primary Target: α-subunits of the Go/Gi group of G-protein
480415
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概述

Replacement Information

重要规格表

Empirical Formula
C₃₅H₂₀N₄O₂₁S₆ · 6Na

Products

产品目录编号包装 数量 / 包装
480415-10MGCN 塑胶安瓿;塑胶针药瓶 10 mg
Description
OverviewA suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go/Gi group (EC50 ~ 300 nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits and βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC50 = 240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle). Causes a concentration dependent inhibition of excitatory junction potentials (IC50 = 4.8 pM).
Catalogue Number480415
Brand Family Calbiochem®
Synonyms8,8ʹ-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I
References
ReferencesSnedden, P., et al. 2000. Br. J. Pharmacol. 129, 1089.
Soto, F., et al. 1999. Neuropharmacology 38, 141.
Beindle, W., et al. 1996. Mol. Pharmacol. 50, 415.
Freissmuth, M., et al. 1996. Mol. Pharmacol. 49, 602.
Product Information
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₃₅H₂₀N₄O₂₁S₆ · 6Na
Chemical formulaC₃₅H₂₀N₄O₂₁S₆ · 6Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetα-subunits of the Go/Gi group of G-protein
Primary Target IC<sub>50</sub>240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle; 4.8 pM in the inhibition of excitatory junction potentials; EC50 ~ 300 nM as G-protein antagonist for α-subunits of the Go/Gi group
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
480415-10MGCN 04055977201345

Documentation

NF023 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

NF023 - Calbiochem 分析证书

标题批号
480415

参考

参考信息概述
Snedden, P., et al. 2000. Br. J. Pharmacol. 129, 1089.
Soto, F., et al. 1999. Neuropharmacology 38, 141.
Beindle, W., et al. 1996. Mol. Pharmacol. 50, 415.
Freissmuth, M., et al. 1996. Mol. Pharmacol. 49, 602.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-June-2018 JSW
Synonyms8,8ʹ-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I
DescriptionA suramin analog that acts as a selective G-protein antagonist for α-subunits of the Go/Gi group (EC50 ~300 nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC50=0.24 µM for P2X1; 8.5 µM for P2X3 receptor in rat muscle).
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₅H₂₀N₄O₂₁S₆ · 6Na
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesSnedden, P., et al. 2000. Br. J. Pharmacol. 129, 1089.
Soto, F., et al. 1999. Neuropharmacology 38, 141.
Beindle, W., et al. 1996. Mol. Pharmacol. 50, 415.
Freissmuth, M., et al. 1996. Mol. Pharmacol. 49, 602.