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14-694M NEK3 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, full length, human NEK3. For use in Kinase Assays.

14-694M
250 µg  Also available in 10 μg size (cat#14-694) and in bulk (cat# 14-694-K).
Purchase on Sigma-Aldrich

概述

Replacement Information
Description
Catalogue Number14-694M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionNEK3 Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant, full length, human NEK3.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, full length, human NEK3. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceHuman NEK3, expressed by baculovirus in Sf21 cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryIn Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized.
Gene Symbol
  • NEK3
  • HSPK36
  • MGC29949
Protein TargetNEK3
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyMisc
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P51956 # Kinase that may play a role in mitotic regulation.
COFACTOR: Magnesium.
SIZE: 506 amino acids; 57705 Da
SIMILARITY: SwissProt: P51956 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. & Contains 1 protein kinase domain.
Molecular Weight62.2kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of MBP (13-104).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C from date of shipment
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-694) and in bulk (cat# 14-694-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
14-694M 04053252582714

Documentation

相关产品和应用

Alternative Packsize

产品目录编号 描述
14-694 NEK3 Protein, active, 10 µg

产品族

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种类

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases