475856 Sigma-AldrichMitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem
The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.
More>> The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor, 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one
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概述
重要规格表
| CAS # | Empirical Formula |
|---|---|
| 338967-87-6 | C₁₅H₁₀Cl₂N₂O₂S |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
|---|---|---|---|
| 475856-10MGCN | 塑胶安瓿;塑胶针药瓶 | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 µM in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50 < 10 µM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- (Cat. Nos. 569396 and 569397) as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release. |
| Catalogue Number | 475856 |
| Brand Family | Calbiochem® |
| Synonyms | Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor, 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one |
| References | |
|---|---|
| References | Cassidy-Stone A., et al. 2008. Dev. Cell 14, 193. |
| Product Information | |
|---|---|
| CAS number | 338967-87-6 |
| Form | White solid |
| Hill Formula | C₁₅H₁₀Cl₂N₂O₂S |
| Chemical formula | C₁₅H₁₀Cl₂N₂O₂S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| 产品目录编号 | GTIN |
| 475856-10MGCN | 07790788056377 |