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FCMAB282F Sigma-AldrichMilli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC

Detect Integrin αVβ3 using this Milli-Mark Anti-Integrin αVβ3 Antibody, clone LM609-FITC validated for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGAV, DKFZp686A08142, MSK8, CD51, VNRA UniProt Number: P06756

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	FC	M	FITC	Monoclonal Antibody

Description
Catalogue Number	FCMAB282F
Trade Name	Milli-Mark
Description	Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC
Alternate Names	Vitronectin Receptor CD51/CD61 integrin alphaVbeta3 alphaVbeta3
Background Information	The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The adhesion receptor, integrin alphaVbeta3, appears to be selectively expressed on growing blood vessels and has been identified as a marker of angiogenic vascular tissue (Brooks, 1994). Due to its involvement in angiogenesis, integrin alphaVbeta3 is one of the most intensely studied of the integrin receptors.

References

Product Information
Format	FITC
Control	U937 cells
Presentation	Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality Level	MQ100

Applications
Application	Detect Integrin αVβ3 using this Milli-Mark Anti-Integrin αVβ3 Antibody, clone LM609-FITC validated for use in FC.
Key Applications	Flow Cytometry

Biological Information
Immunogen	Purified adhesion receptor from the human melanoma cell line M21 (Cherish, D. and Spiro, R. (1987) J. Biol. Chemistry, 262(36):17703-17711).
Clone	LM609
Host	Mouse
Specificity	Antibody recognizes Integrin αVβ3.
Isotype	IgG1
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_002201
Gene Symbol	ITGAV DKFZp686A08142 MSK8 CD51 VNRA
Purification Method	Protein A Purfied
UniProt Number	P06756
UniProt Summary	FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. SIZE: 1048 amino acids; 116038 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by flow cytometry using U937 cells.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Flow Cytometry Antibody dilution for cellular staining: • Prepare an antibody working solution by diluting the primary antibody 1:5 with PBS • Dispense the volume per test of working of solution according to the number of cells indicated in the table below. • 5 µL for Guava Flow Cytometer • 10 µL for other Flow Cytometry instruments

Packaging Information
Material Size	100 tests

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
FCMAB282F	04053252415371

Documentation

Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC MSDS

职位
物料安全数据表 (MSDS)

Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC 分析证书

标题	批号
Milli-Mark Anti-Integrin #945;V#946;3-FITC, clone LM609 - 2161157	2161157
Milli-Mark Anti-Integrin V3-FITC, clone LM609 - 1951937	1951937
Milli-Mark Anti-Integrin V3-FITC, clone LM609 - 2032727	2032727
Milli-Mark Anti-Integrin V3-FITC, clone LM609 - 2073083	2073083
Milli-Mark Anti-Integrin V3-FITC, clone LM609 - NG1932865	NG1932865
Milli-Mark Anti-Integrin V3-FITC, clone LM609 - NG1944975	NG1944975
Milli-Mark Anti-Integrin V3-FITC, clone LM609 - NRG1859106	NRG1859106
Milli-Mark Anti-Integrin αVβ3-FITC, clone LM609	3159369
Milli-Mark Anti-Integrin αVβ3-FITC, clone LM609 - 3940994	3940994
Milli-Mark Anti-Integrin αVβ3-FITC, clone LM609 -2509127	2509127

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种类

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