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474700 Mevastatin - CAS 73573-88-3 - Calbiochem

An antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation.

Mevastatin - CAS 73573-88-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Compactin

Primary Target: HMG-CoA reductase
474700
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
73573-88-3C₂₃H₃₄O₅

Products

产品目录编号包装 数量 / 包装
474700-50MGCN 塑胶安瓿;塑胶针药瓶 50 mg
Description
OverviewAn antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation. Inhibitor of myoblast fusion. Also may induce bone morphogenic protein-2 (BMP-2). Causes cell cycle arrest in late G1 phase.
This is an inactive form which may require activation for use with isolated cells depending upon the application. To activate, treat with NaOH in ethanol and then neutralize to pH 7.2.
Catalogue Number474700
Brand Family Calbiochem®
SynonymsCompactin
References
ReferencesSugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.
Product Information
CAS number73573-88-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₃H₃₄O₅
Chemical formulaC₂₃H₃₄O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHMG-CoA reductase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEK7907100
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
474700-50MGCN 07790788050429

Documentation

Mevastatin - CAS 73573-88-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Mevastatin - CAS 73573-88-3 - Calbiochem 分析证书

标题批号
474700

参考

参考信息概述
Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-August-2008 RFH
SynonymsCompactin
DescriptionAn antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppresses Ras farnesylation. Inhibitor of myoblast fusion. Causes cell cycle arrest in late G1 phase. May induce bone morphogenic protein-2 (BMP-2). This product requires activation for use in cell culture and cell-free assay systems. To activate, treat with ethanol solution with 1 N NaOH and then neutralize with 1 N HCl to pH 7.2 (see Keyomarsi, K . et al. 1991).
FormWhite solid
CAS number73573-88-3
RTECSEK7907100
Chemical formulaC₂₃H₃₄O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityEthanol
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 6164
ReferencesSugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688.
Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682.
Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159.
McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763.
Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042.
Kita, T., et al. 1980. J. Clin. Invest. 66, 1094.