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444249 MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem

The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS

Primary Target: MMP-2
444249
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
193807-60-2C₂₁H₂₀N₂O₄S

Products

产品目录编号包装 数量 / 包装
444249-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
OverviewA potent inhibitor of MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
Catalogue Number444249
Brand Family Calbiochem®
Synonyms(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS
References
ReferencesLauzier, M.C., et al. 2008. Mol. Pharmacol. In press.
Mifune, M., et al. 2005. J. Biol. Chem. 280, 26592.
Zhang, H., et al. 2004. Circ. Res. 95, 989.
Tamura, Y., et al. 1998. J. Med. Chem. 41, 640.
Product Information
CAS number193807-60-2
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₁H₂₀N₂O₄S
Chemical formulaC₂₁H₂₀N₂O₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-2
Primary Target IC<sub>50</sub>17 nM, 30 nM against MMP-2, and MMP-9, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
444249-1MGCN 04055977186499

Documentation

MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem 分析证书

标题批号
444249

参考

参考信息概述
Lauzier, M.C., et al. 2008. Mol. Pharmacol. In press.
Mifune, M., et al. 2005. J. Biol. Chem. 280, 26592.
Zhang, H., et al. 2004. Circ. Res. 95, 989.
Tamura, Y., et al. 1998. J. Med. Chem. 41, 640.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-April-2011 RFH
Synonyms(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS
DescriptionA potent inhibitor of type IV collagenases, MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Has been shown in vivo to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number193807-60-2
Chemical formulaC₂₁H₂₀N₂O₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Methanol (25 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLauzier, M.C., et al. 2008. Mol. Pharmacol. In press.
Mifune, M., et al. 2005. J. Biol. Chem. 280, 26592.
Zhang, H., et al. 2004. Circ. Res. 95, 989.
Tamura, Y., et al. 1998. J. Med. Chem. 41, 640.