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444258 MMP-14 Substrate I, Fluorogenic - Calbiochem

A specific fluorescence resonance energy transfer (FRET) peptide substrate for the detection of MMP activity.

MMP-14 Substrate I, Fluorogenic - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: MT1-MMP Substrate I, Fluorogenic, MCA-PLA-C(OMeBz)-WAR(Dpa)-NH₂

444258
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概述

Replacement Information

Products

产品目录编号包装 数量 / 包装
444258-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
OverviewA specific fluorescence resonance energy transfer (FRET) peptide substrate for the detection of MMP activity. (kcat/Km = 7.3 x 105 M-1s-1 for MMP-14 (MT1-MMP) and 3.6 x 104 M-1s-1 for MMP-11 at 25°C, pH 7.5).
Catalogue Number444258
Brand Family Calbiochem®
SynonymsMT1-MMP Substrate I, Fluorogenic, MCA-PLA-C(OMeBz)-WAR(Dpa)-NH₂
References
ReferencesMucha, A., et al. 1998. J. Biol. Chem. 273, 2763.
Product Information
ATP CompetitiveN
FormYellow lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₆₆H₈₂N₁₆O₁₇S
Chemical formulaC₆₆H₈₂N₁₆O₁₇S
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-14
Primary Target IC<sub>50</sub>kcat/Km = 7.3 x 105 M-1s-1 for MMP-14; .6 x 104 M-1s-1 for MMP-11
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Emission max.
Excitation max.
Peptide SequenceMCA-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg(Dpa)-NH₂ Dpa = N³-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl, Bz = Benzyl
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
444258-1MGCN 04055977186550

Documentation

MMP-14 Substrate I, Fluorogenic - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

MMP-14 Substrate I, Fluorogenic - Calbiochem 分析证书

标题批号
444258

参考

参考信息概述
Mucha, A., et al. 1998. J. Biol. Chem. 273, 2763.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-March-2009 JSW
SynonymsMT1-MMP Substrate I, Fluorogenic, MCA-PLA-C(OMeBz)-WAR(Dpa)-NH₂
DescriptionA fluorescence resonance energy transfer (FRET) peptide substrate for the detection of MMP activity (kcat/km = 730,000 M-1s-1 for MMP-14 (MT1-MMP) and 36,000 M-1s-1 for MMP-11 (ST3); pH = 7.5 at 25°C). Excitation max.: ~328 nm; emission max.: ~400 nm.
FormYellow lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₆₆H₈₂N₁₆O₁₇S
Peptide SequenceMCA-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg(Dpa)-NH₂ Dpa = N³-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl, Bz = Benzyl
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMucha, A., et al. 1998. J. Biol. Chem. 273, 2763.