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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

475882 Sigma-AldrichML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl

Primary Target: Mlck

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
105637-50-1	C₁₅H₁₇ClN₂O₂S · HCl

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Description
Overview	A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.
Catalogue Number	475882
Brand Family	Calbiochem®
Synonyms	1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl

References
References	Reig, J.A., et al. 1993. Neurochem. Res. 18, 317. Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1045. Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796. Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun. 140, 280.

Product Information
CAS number	105637-50-1
ATP Competitive	Y
Form	White solid
Hill Formula	C₁₅H₁₇ClN₂O₂S · HCl
Chemical formula	C₁₅H₁₇ClN₂O₂S · HCl
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Mlck
Primary Target K<sub>i</sub>	3.8 µM, 32 µM, 54 µM against myosin light chain kinase, protein kinase A, and protein kinase C, respectively
Purity	≥98% by TLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
475882-1MGCN	04055977203509

Documentation

ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem 分析证书

标题	批号
475882	输入批号

参考

参考信息概述
Reig, J.A., et al. 1993. Neurochem. Res. 18, 317. Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1045. Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796. Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun. 140, 280.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-September-2018 JSW
Synonyms	1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl
Description	A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.
Form	White solid
CAS number	105637-50-1
Chemical formula	C₁₅H₁₇ClN₂O₂S · HCl
Structure formula
Purity	≥98% by TLC
Solubility	50% Ethanol (10 mg/ml). Further dilute with aqueous buffer just prior to use.
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity	Standard Handling
References	Reig, J.A., et al. 1993. Neurochem. Res. 18, 317. Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1045. Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796. Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun. 140, 280.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors

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475882 Sigma-AldrichML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM).

同义词: 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl

Recommended Products

概述

重要规格表

Products

Documentation

ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem MSDS

ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem 分析证书

参考

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A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (Ki = 3.8 µM), protein kinase A (Ki = 32 µM), and protein kinase C (Ki = 54 µM).

同义词: 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl

Recommended Products

重要规格表

Products

ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem MSDS

ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem 分析证书

参考

种类

最近查看的内容

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM).