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444180 MAP Kinase Inhibitor Set I - Calbiochem

The MAP Kinase Inhibitor Set I controls the biological activity of MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MAP Kinase Inhibitor Set I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: p38 kinase
444180
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概述

Replacement Information

Products

产品目录编号包装 数量 / 包装
444180-1SETCN 玻璃瓶 1 set
Description
OverviewContains 5 mg of the MEK inhibitor PD 98059 (Cat. No. 513000), 1 mg each of the MAP kinase inhibitors SB 202190 (Cat. No. 559388) and SB 203580 (Cat. No. 559389), and 1 mg of Proteasome Inhibitor I (Cat. No. 539160), which serves as a negative control. Supplied with a data sheet.
Catalogue Number444180
Brand Family Calbiochem®
References
Product Information
FormSolid
Quality LevelMQ100
Applications
Biological Information
Primary Targetp38 kinase
Primary Target IC<sub>50</sub>350 nM, 600 nM
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and store at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
444180-1SETCN 04055977205527

Documentation

MAP Kinase Inhibitor Set I - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

MAP Kinase Inhibitor Set I - Calbiochem 分析证书

标题批号
444180

小册子

标题
Protein Kinase Assay and Detection Kits Brochure
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-August-2020 JSW
DescriptionMAP (mitogen-activated protein) kinases are ubiquitous serine/threonine kinases that are activated by a wide variety of extracellular signals. The MAP kinase cascade plays a crucial role in signal transduction from the membrane to the nucleus and appears to be highly conserved throughout evolution. In mammalian cells, this cascade is activated by both tyrosine kinase receptors and G-protein coupled receptors. MAP kinase activation, an essential step in triggering cell cycle progression, leads to changes in properties of cytoplasmic, membrane-associated and nuclear proteins. A unique feature of MAP kinases is that their full activation requires phosphorylation of both a threonine residue and a tyrosine residue which are separated by a single amino acid. This phosphorylation is brought about by the action of MAP kinase kinase (MEK), a dual specificity kinase. Once activated, MAP kinase relays signals downstream by phosphorylating various other protein kinases and regulatory proteins. Following activation, MAP kinases translocate from the cytosol into the nucleus and phosphorylate a number of transcription factors leading to changes in gene expression. Supplied with a data sheet.
FormSolid
SolubilityThese inhibitors are soluble in DMSO.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and store at -20°C.
Toxicity Standard Handling